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|Product Name:||Procaine HCL||Assay:||99%|
|Melting Point:||155-156 °C||Grade:||Pharmaceutical Grade|
|Storage:||Shading, Confined Preservation||Appearance:||White Crystalline Powder|
|Alias:||Neocaine Anadolor Aminocaine||Key Word:||Local Anesthetics|
Pharmaceutical raw material powder Pain killer Procaine HCl dosage effect
Product name: Procaine hydrochloride ;Procaine HCl
Appearance:white crystalline powder
Usage:Local anesthesic ;Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
Benzocaine base: / benzocaine /benzocaine/ procaine / lidocaine / lidocaie hcl / procaine hcl
CAS No.: 94-09-7
Appearance: White Crystal Powder
Usage: Local anesthetic.
Standard: USP/BP standard
Chemical Name: Lidocaine
Molecular Formula: C14H22N2O
Formula Weight: 234.34
CAS No.: 137-58-6
Usage: Local anesthetics
Peoduct name: Lidocaine hydrochloride
Melting point: 350.8° C at 760 mmHg
Usage: Local anesthetics, antiarrhythmic drugs, used for a variety of anesthesia and rapid ventricular arrhythmia
Product name: Procaine
CAS No.: 59-46-1
Appearance: White Crystalline Powder
Place of Origin: China
Usage: Local anesthetics
3. Procaine HCl Specification
|Product name||Procaine HCl|
|Appearance||White crystalline powder|
|Assay (C13H20N2O2¡¤HCl)||99.0% to 101.0%||99.5%|
|Acidity||≤0.02N NaOH 0.5ml||0.3ml|
|Chromatographic purity||Secondary spots≤0.5%,sum≤1.0%||Conforms|
|Loss on drying||≤1.0%||0.06%|
|Residue on ignition||≤0.15%||0.03%|
Procaine hydrochloride Description
Prasaine hydrochloride is a local anesthetic, can temporarily block the nerve fiber conduction and anesthesia, the role of strong, low toxicity, no addiction, but the skin, mucosal permeability is weak, not suitable for surface anesthesia, the main clinical use In infiltration, spinal cord and conduction anesthesia.
White needle crystal or crystalline powder at room temperature odorless, bitter bitter bitter, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Ester chain in the pracaine hydrochloride structure can be hydrolyzed to produce amino acids and diethylamino ethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylation to produce toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino groups, easy to oxidize discoloration of pH, temperature, UV, oxygen and metal ions can accelerate oxidative discoloration. The aqueous solution was stable in pH 3.0 to 5. Therefore, the preparation of procaine hydrochloride injection usually need to add acid to adjust pH 3.3 ~ 5.5, strictly control the sterilization temperature and time. To 100 ℃ steam sterilization 30min cycle is appropriate, and should pay attention to the shadow, sealed to save.
The product structure of the aromatic primary amino group in the dilute hydrochloric acid can produce the diazonium salt of sodium nitrite. When the basic naphthol is added, the coupling reaction occurs and the azo compound is scarlet.
Procaine hydrochloride Usage
Procaine HCl is a local anesthetic drug for amino ester groups. It is mainly used to reduce intramuscular injection of penicillin pain, can also be used for dental use. As the merchandise name Novocain is everywhere, in some areas procaine is often referred to as Novak. Its main role is sodium channel blockers. Because of their sympathy, anti-inflammatory, perfusion enhancement and emotional enhancement, in some countries are used for treatment.
The application of procaine leads to inhibition of neuronal activity. Depression makes the nervous system become allergic, causing anxiety and vibration, leading to mild to severe convulsions. Studies of animals have shown that the use of procaine causes an increase in dopamine and serotonin levels in the brain. Other problems may vary depending on the individual's tolerance to procaine dose. Central nervous system excitation can cause tension and dizziness, if excessive coordination may lead to respiratory failure. Procaine may also cause myocardial ischemia leading to cardiac arrest.
Procaine can also cause allergic reactions, leading to individual breathing, rash and swelling problems. The allergic reaction to procaine is usually not for procaine itself, but its metabolite, PABA. Approximately one of about 3,000 people has an atypical form of pseudo-alkaline esterase, which does not require hydrolysis of anesthetic, such as procaine, resulting in increased levels of narcotics in the blood and increased toxicity.
Procaine hydrochloride discovery and use
Pracaine hydrochloride was first synthesized by the German chemist Albert Einhorn in 1905. He is looking for a can be used as anesthetic, non-toxic, no side effects, no addiction compounds. Dr. Eindhoven is looking for a compound that can replace cocaine as an anesthetic. Cocaine is used as an anesthetic. However, since cocaine is toxic, addictive, destructive to the central nervous system, its use is illegal. Dr. Einhorn was able to produce a compound that showed the property he was looking for. This new compound is called procaine.
"Pro" refers to a substitute, "cocaine" comes from the word cocaine. Because these names are similar, because they are anesthetized, the nature of procaine has a lot of confusion. Sporaine acts as an anesthetic when injected into muscle, but when combined as a compound, procaine is used as a vitamin. The procaine hydrochloride solution used as an anesthetic is called Norcaine.
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