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Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay

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Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay

China Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay supplier

Large Image :  Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay

Product Details:

Place of Origin: China
Brand Name: YC
Certification: ISO9001, ISO14001, USP
Model Number: 62-44-2

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: Discreet ways of packing for Customs pass guaranteed
Delivery Time: within 24hours after payment
Payment Terms: Western Union, T/T, MoneyGram, Bitcoin
Supply Ability: Plenty of stock
Detailed Product Description
Product Name: Phenacetin CAS No.: 62-44-2
Assay: 99% EINECS No.: 200-533-0
MOQ: 10g Customs Pass Rate: 99%
Delivery Time: Within 24 Hours Shipping Time: 3-7 Working Days
Specification: Local Anesthetic Drugs Key Word: 99.5% Assay Phenacetin
Character: White Or Almost White Crystalline Powder

Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay

 

 

Quick Detail:

Product Name: Phenacetin
CAS: 62-44-2
EINECS: 200-533-0
Assay: 99%
Formula: C10H13NO2
MW: 179.2157
Density: 1.099g / cm3
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses: Anti-inflammatory drugs
Appearance: White or almost white crystalline powder
Export Markets: Global

 


Description

 

The painkiller phenacetin was the world's first synthetic pharmaceutical drug. It was developed by an American chemist and began distribution in 1887. Phenacetin was often accompanied by aspirin and caffeine in what were called APC pills, which were widely distributed during and after World War II. The use of phenacetin in the U.S. was discontinued in the 1980s because of links to cancer and other adverse side effects, but it remains available in some countries.

 

Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.

 

In 1983, the U.S. Food and Drug Administration (FDA) banned phenacetin in the U.S. because of its discovered carcinogenic properties and its link to kidney failure. The FDA stated that phenacetin alone is reasonably believed to be a human carcinogen, or cancer-causing agent, and that painkiller mixtures containing the drug are known human carcinogens. There has been little evidence found that phenacetin alone is a human carcinogen because it usually has been administered in combination with other drugs.

 

 

Application

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). Phenacetin was also banned in India.

As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenaceti.

Phenacetin is a metabolite of phenacetiwith similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.

Due to low cost phenacetin is used for research into the physical and refractive properties of crystals.
Phenacetin is an ideal compound for this type of research.

 


Preparation

 

The first synthesis was reported in 1878 by Harmon Northrop Morse.

Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are refluxed in 2-butanone to give the crude product, which is recrystallized from water.


Uses

 

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India. As a result, some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.

 

Due to low-cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

 

Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay


Safety

 

Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases. In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.

 

Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. This is a condition which results in destruction of some or all of the renal papillae in the kidneys.

One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.

 


Packaging & Delivery:


1. Professional team for package and shipment.Special way to ship 100grams to 100kg powders at one time to your country.
2. Fast and discreet shipment could be arranged for customs pass Guaranteed.
3. Tracking code 24 hours for customs pass guaranteed.
4. Many kinds of shipment, also can be as your requirement.

 

 

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1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2. We have a more profound professional knowledge, you can do a full range of services.
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Supply CAS 62-44-2 Local Anesthetic Drugs Phenacetin Raw Powder 99.5% Assay

 

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